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Episode 284 – Insulin – More than just a Sweet Companion

In today’s episode of the ATP Project, the team meets to share collective knowledge on all things insulin. They discuss how insulin works, situations where its function can be disrupted such as in the case of insulin resistance and, how insulin impacts performance outcomes. So many gold nuggets in this episode!

References:

  1. Keske, M. A., Premilovac, D., Bradley, E. A., Dwyer, R. M., Richards, S. M., & Rattigan, S. (2016). Muscle microvascular blood flow responses in insulin resistance and ageing. The Journal of physiology594(8), 2223–2231. https://doi.org/10.1113/jphysiol.2014.283549
  2. Vascular function, insulin action, and exercise: an intricate interplay
    Author links open overlay panelChaoZheng1ZhenqiLiu2
  3. Steinberg, Helmut & Brechtel, G & Johnson, A & Fineberg, N & Baron, Alain. (1994). Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. The Journal of clinical investigation. 94. 1172-9. 10.1172/JCI117433.
  4. Wong, R., & Howe, P. (2018). Resveratrol Counteracts Insulin Resistance-Potential Role of the Circulation. Nutrients10(9), 1160. https://doi.org/10.3390/nu10091160
  5. Carlo Dal Lin, Francesco Tona, Elena Osto, “Coronary Microvascular Function and Beyond: The Crosstalk between Hormones, Cytokines, and Neurotransmitters”, International Journal of Endocrinology, vol. 2015, Article ID 312848, 17 pages, 2015. https://doi.org/10.1155/2015/312848
  6. Chen, R. H., Chen, H. Y., Man, K. M., Chen, S. J., Chen, W., Liu, P. L., Chen, Y. H., & Chen, W. C. (2019). Thyroid diseases increased the risk of type 2 diabetes mellitus: A nation-wide cohort study. Medicine98(20), e15631. https://doi.org/10.1097/MD.0000000000015631
  7. Lindner J. R. (2018). Cause or Effect? Microvascular Dysfunction in Insulin-Resistant States. Circulation. Cardiovascular imaging11(4), e007725. https://doi.org/10.1161/CIRCIMAGING.118.007725
  8. REVIEW| VOLUME 51, 102590, JANUARY 01, 2020 Role of gut microbiota in type 2 diabetes pathophysiology Manoj Gurung 1 Zhipeng Li 1 Hannah You 1 Richard Rodrigues Donald B Jump Andrey Morgun et al. Open AccessPublished: January 03, 2020DOI: https://doi.org/10.1016/j.ebiom.2019.11.051
  9. Chaker, L., Ligthart, S., Korevaar, T.I.M. et al. Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study. BMC Med 14, 150 (2016). https://doi.org/10.1186/s12916-016-0693-4
  10. Blagosklonny M. V. (2019). The mystery of the ketogenic diet: benevolent pseudo-diabetes. Cell cycle (Georgetown, Tex.)18(18), 2157–2163. https://doi.org/10.1080/15384101.2019.1644765
  11. Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity Author links open overlay panelXinZenga1Yuan-jieXieab1Ya-tingLiuacShuang-lianLongaZhong-chengMoab. https://doi.org/10.1016/j.cca.2019.11.003

  12. Liu, Y., Ye, W., Chen, Q., Zhang, Y., Kuo, C. H., & Korivi, M. (2019). Resistance Exercise Intensity is Correlated with Attenuation of HbA1c and Insulin in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. International journal of environmental research and public health16(1), 140. https://doi.org/10.3390/ijerph16010140
  13. A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of body weight loss. Author links open overlay panel Fernando F.Anhê12Renato T.Nachbar1Thibault V.Varinhttps://doi.org/10.1016/j.molmet.2017.10.003